OS、PFS、DFS 有什么区别？一文搞懂 6 大肿瘤临床试验终点
让我们一起来看看常用的 OS、PFS、DFS、TTP、TTF、ORR 都有什么区别以及优缺点。. 总生存（Overall survival，OS）. 定义为：从随机化开始至（因任何原因）死亡的时间. 被认为是肿瘤临床试验中最佳的疗效终点， 当患者的生存期能充分时，它通常是首选终点。. 最大的 ...
Clinical endpoints in oncology - a primer - PMC - National Center …
Apr 15, 2021 · Progression free survival (PFS) is defined as the time from randomization until first evidence of disease progression or death . PFS is measured by censoring and patients who are still alive at the time of evaluation or those who were lost to follow up .
Progression-free survival, disease-free survival and other …
Oct 12, 2023 · Progression-free survival (PFS), disease-free survival (DFS), relapse-free survival (RFS) and event-free survival (EFS) are among the most common end points used in oncology clinical trials...
Overall Response Rate, Progression-Free Survival, and Overall …
Feb 9, 2015 · To conduct analyses exploring trial-level and patient-level associations between overall response rate (ORR), progression-free survival (PFS), and overall survival (OS) in advanced non–small-cell lung cancer (NSCLC) trials.
Relationship between Progression-free Survival and Overall …
Jun 9, 2019 · Progression-free survival (PFS), the time from treatment initiation until disease progression or worsening, may be used as a direct or surrogate measure of clinical benefit for drug approvals, depending on the disease and response observed, while overall survival (OS), the duration of patient survival from the time of treatment initiation, is a ...
Progression-free survival as a surrogate for overall survival in ...
Mar 26, 2020 · Progression-free survival (PFS) is a surrogate endpoint widely used for overall survival (OS) in oncology. Validation of PFS as a surrogate must be done for each indication and each...
Association between progression-free survival and overall survival …
Mar 8, 2023 · Overall survival (OS) is the gold standard endpoint to assess treatment efficacy in cancer clinical trials. In metastatic breast cancer (mBC), progression-free survival (PFS) is commonly used as an intermediate endpoint. Evidence remains scarce regarding the degree of association between PFS and OS.
Guidelines for time-to-event end point definitions in breast cancer ...
Jan 30, 2014 · Two definitions for two different end points were identical: distant DFS (D-DFS) and distant relapse-free survival (D-RFS). The reference date was usually the date of randomization, but it could also be the date of diagnosis or …
Intermediate clinical endpoints: A bridge between …
Oct 21, 2014 · PFS and OS can be regarded as proximal and distal endpoints, respectively. The degree of correlation between PFS and OS is affected by the duration of the postprogression survival (PPS) period, with a longer PPS period potentially leading to a dilution of the PFS treatment effect.
Overview: Progression-Free Survival as an Endpoint in Clinical …
May 12, 2013 · Progression-free survival (PFS) is increasingly used as an important and even a primary endpoint in randomized cancer clinical trials in the evaluation of patients with solid tumors for both practical and clinical considerations.